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Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report

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Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report

Auteurs : Ann Woolfrey [États-Unis] ; Jan Storek [États-Unis, Canada] ; Suzanne Bowyer [États-Unis] ; Robert Nelson [États-Unis] ; Michael Robertson [États-Unis] ; Carol Wallace [États-Unis]

Source :

RBID : ISTEX:0EB32AA5408255EF26EDD448B9DAE16B3E8A9394

Abstract

Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract:  Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.

Url:
DOI: 10.1111/j.1399-3046.2009.01129.x


Affiliations:


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Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract:  Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</div>
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