Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report
Identifieur interne : 001701 ( Main/Exploration ); précédent : 001700; suivant : 001702Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report
Auteurs : Ann Woolfrey [États-Unis] ; Jan Storek [États-Unis, Canada] ; Suzanne Bowyer [États-Unis] ; Robert Nelson [États-Unis] ; Michael Robertson [États-Unis] ; Carol Wallace [États-Unis]Source :
- Pediatric Transplantation [ 1397-3142 ] ; 2010-09.
Abstract
Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.
Url:
DOI: 10.1111/j.1399-3046.2009.01129.x
Affiliations:
- Canada, États-Unis
- Alberta, Indiana, Washington (État)
- Calgary, Seattle
- Université de Calgary, Université de Washington
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<front><div type="abstract" xml:lang="en">Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.</div>
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